Sharon E. Plon is a diplomat of the American Board of Medical Genetics and Genomics. She received her MD and PhD (Biophysics) degrees from Harvard University and completed her medical genetics clinical training at the University of Washington. Dr. Plon has been a faculty member of Baylor College of Medicine and Texas Children’s Hospital for 25 years. She is now Professor in the Departments of Pediatrics/Hematology-Oncology, Molecular and Human Genetics and Human Genome Sequencing Center. Drs. Plon and D. William Parsons were principal investigators of the NHGRI/NCI-funded BASIC3 clinical trial on the incorporation of exome sequencing into the care of newly diagnosed childhood cancer patients and this study is now being expanded into several different centers in Texas (KidsCanSeq trial. Dr. Plon serves on the National Advisory Council for Human Genome Research of the NIH and is a member of the Board of Directors of the American Society of Human Genetics. Dr. Plon also co-chairs the germline reporting committee of the Children’s Oncology Group/NCI Pediatric MATCH national precision oncology trial which opened in August 2017. Since 2013, Dr. Plon has served as one of the Principal Investigators of the NIH-supported Clinical Genome (ClinGen) Resource and chairs the ClinGen Hereditary Cancer Clinical Domain Working Group.